The Rotavirus NSP4 Viroporin Domain is a Calcium-conducting Ion Channel
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منابع مشابه
The Rotavirus NSP4 Viroporin Domain is a Calcium-conducting Ion Channel
Viroporins are small virus-encoded ion channel proteins. Most viroporins are monovalent selective cation channels, with few showing the ability to conduct divalent cations, like calcium (Ca2+). Nevertheless, some viroporins are known to disrupt host cell Ca2+ homeostasis, which is critical for virus replication and pathogenesis. Rotavirus nonstructural protein 4 (NSP4) is an endoplasmic reticul...
متن کاملRotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity
Many viruses alter intracellular calcium homeostasis. The rotavirus nonstructural protein 4 (NSP4), an endoplasmic reticulum (ER) transmembrane glycoprotein, increases intracellular levels of cytoplasmic Ca(2+) ([Ca(2+)]cyto) through a phospholipase C-independent pathway, which is required for virus replication and morphogenesis. However, the NSP4 domain and mechanism that increases [Ca(2+)]cyt...
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Rotavirus nonstructural protein 4 (NSP4) induces dramatic changes in cellular calcium homeostasis. These include increased endoplasmic reticulum (ER) permeability, resulting in decreased ER calcium stores and activation of plasma membrane (PM) calcium influx channels, ultimately causing a 2- to 4-fold elevation in cytoplasmic calcium. Elevated cytoplasmic calcium is absolutely required for viru...
متن کاملGroup A Rotavirus NSP4 is Under Negative Selective Pressure
Rotavirus (RV) is the major etiologic agent of severe infantile gastroenteritis; its genome has 11 segments of double stranded RNA, encoding 12 proteins. The non-structural protein 4 (NSP4) encoded by segment 10 is multifunctional. The aim of this study is to analyze the selective pressure driving the NSP4 of RV, through the ratio of non-synonymous substitutions per synonymous substitutions (dN...
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Objective(s): The rotavirus nonstructural protein 4 (NSP4) is responsible for the increase in cytoplasmic calcium concentration through a phospholipase C-dependent and phospholipase C-independent pathways in infected cells. It is shown that increasing of intracellular calcium concentration in rotavirus infected cells is associated with the activation of some members of protein kinases family su...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/srep43487